Literature summary for 3.4.24.B20 extracted from

Obrist, M.; Langklotz, S.; Milek, S.; Fuehrer, F.; Narberhaus, F.
Region C of the Escherichia coli heat shock sigma factor RpoH (sigma 32) contains a turnover element for proteolysis by the FtsH protease (2009), FEMS Microbiol. Lett., 290, 199-208.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RpoH + H2O	Escherichia coli	RpoH is rapidly degraded by chaperone-mediated FtsH-dependent proteolysis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mutational substrate analysis, structure-function anaylsis, modelling, overview	Escherichia coli	?	-	?
RpoH + H2O	RpoH is rapidly degraded by chaperone-mediated FtsH-dependent proteolysis	Escherichia coli	?	-	?
RpoH + H2O	several RpoH residues critical for degradation are located in the highly conserved region 2.1. The double mutation A131E/K134V significantly stabilizes RpoH against degradation by the FtsH protease, while the single-point mutations at these positions only show a slight effect on RpoH stability. A minimal RpoH variant composed of residues L37-G147, including region 2.1 and C, is a sufficient FtsH substrate. Region 2.1 and region C might serve as interaction surfaces for FtsH-mediated degradation	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)