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Literature summary for 3.4.24.B19 extracted from
- The mitochondrial quality control protein Yme1 is necessary to prevent defective mitophagy in a yeast model of Barth syndrome (2015), J. Biol. Chem., 290, 9284-9298.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | - |
Saccharomyces cerevisiae | 31966 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
| Saccharomyces cerevisiae BY4741 | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| YME1 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mutations in the catalytic subunit of the i-AAA protease complex cause an elevated rate of mitochondrial turnover. Inactivation of the enzyme results in a slight increase in H2O2 sensitivity; while inactivation of both TAZ1 and YME1 together results in a dramatic increase in H2O2 sensitivity | Saccharomyces cerevisiae |
| physiological function | the protease Yme1 is required for efficient mitophagy in the absence of tafazzin. The catalytic subunit of the i-AAA protease complex is responsible for degradation of unfolded or misfolded mitochondrial gene products and also has a role in intermembrane space protein folding | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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