Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bortezomib | - |
Homo sapiens | |
MG132 | - |
Homo sapiens | |
additional information | not inhibited by epoxomicin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
HMG1-phosphorylated mitochondrial transcription factor A + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | DNA-bound mitochondrial transcription factor A is resistant to proteolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
HMG1-phosphorylated mitochondrial transcription factor A + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | DNA-bound mitochondrial transcription factor A is resistant to proteolysis | Homo sapiens | ? | - |
? | |
rhodamine 110, bis-(Cbz-L-alanyl-L-alanine amide) + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lon protease | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | required | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000017 | - |
at 37°C, pH not specified in the publication | Homo sapiens | bortezomib |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown stabilizes mitochondrial transcription factor A in mitochondrial DNA-deficient cells and upregulates mitochondrial DNA DNA | Homo sapiens |