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Literature summary for 3.4.24.B18 extracted from

  • Lu, B.; Lee, J.; Nie, X.; Li, M.; Morozov, Y.I.; Venkatesh, S.; Bogenhagen, D.F.; Temiakov, D.; Suzuki, C.K.
    Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease (2013), Mol. Cell, 49, 121-132.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
bortezomib
-
Homo sapiens
MG132
-
Homo sapiens
additional information not inhibited by epoxomicin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
HMG1-phosphorylated mitochondrial transcription factor A + H2O Homo sapiens
-
?
-
?
additional information Homo sapiens DNA-bound mitochondrial transcription factor A is resistant to proteolysis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HMG1-phosphorylated mitochondrial transcription factor A + H2O
-
Homo sapiens ?
-
?
additional information DNA-bound mitochondrial transcription factor A is resistant to proteolysis Homo sapiens ?
-
?
rhodamine 110, bis-(Cbz-L-alanyl-L-alanine amide) + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
lon protease
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP required Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000017
-
at 37°C, pH not specified in the publication Homo sapiens bortezomib

General Information

General Information Comment Organism
malfunction enzyme knockdown stabilizes mitochondrial transcription factor A in mitochondrial DNA-deficient cells and upregulates mitochondrial DNA DNA Homo sapiens