Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B18 extracted from

  • Botelho, S.C.; Tatsuta, T.; von Heijne, G.; Kim, H.
    Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria (2013), J. Biol. Chem., 288, 4792-4798.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B18

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane inner mitochondrial membrane Saccharomyces cerevisiae 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytochrome c peroxidase 1 + H2O Saccharomyces cerevisiae cleaved at Ala29 in the middle of the hydrophobic segment by the inner membrane m-AAA protease complex ?
-
 ?
cytochrome c peroxidase 1 + H2O Saccharomyces cerevisiae W303-1A cleaved at Ala29 in the middle of the hydrophobic segment by the inner membrane m-AAA protease complex ?
-
 ?
additional information Saccharomyces cerevisiae Mgm1 is not a substrate of the enzyme ?
-
 ?
additional information Saccharomyces cerevisiae W303-1A Mgm1 is not a substrate of the enzyme ?
-
 ?
MrpL32 + H2O Saccharomyces cerevisiae
-
 ?
-
 ?
MrpL32 + H2O Saccharomyces cerevisiae W303-1A
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae W303-1A
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytochrome c peroxidase 1 + H2O cleaved at Ala29 in the middle of the hydrophobic segment by the inner membrane m-AAA protease complex Saccharomyces cerevisiae ?
-
 ?
cytochrome c peroxidase 1 + H2O cleaved at Ala29 in the middle of the hydrophobic segment by the inner membrane m-AAA protease complex Saccharomyces cerevisiae W303-1A ?
-
 ?
additional information Mgm1 is not a substrate of the enzyme Saccharomyces cerevisiae ?
-
 ?
additional information Mgm1 is not a substrate of the enzyme Saccharomyces cerevisiae W303-1A ?
-
 ?
MrpL32 + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
MrpL32 + H2O
-
 Saccharomyces cerevisiae W303-1A ?
-
 ?

Synonyms

Synonyms Comment Organism
Yta10
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism the m-AAA protease dislocates transmembrane segments from the mitochondrial inner membrane. The presence of the m-AAA protease increases the hydrophobicity required for a transmembrane segment to remain in the membrane. The m-AAA protease is a central component of the mitochondrial protein quality control system, being able to extract and degrade misfolded polypeptides from the inner membrane Saccharomyces cerevisiae