Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | inner mitochondrial membrane | Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebral cortical neuron | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
AFG3L2 | subunit | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in subunit AFG3L2 are associated with spinocerebellar ataxia SCA28. Depletion of subunit AFG3L2 leads to a specific defect of anterograde transport of mitochondria in cortical neurons. Deletion of subunit AFG3L2 in adult cortical neurons causes tau hyperphosphorylation and activation of protein kinase A and ERK1/2 kinases | Mus musculus |
physiological function | subunit AFG3L2 is required cell-autonomously for survival of adult neurons | Mus musculus |