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Literature summary for 3.4.24.B18 extracted from
- Mitochondrial AAA proteases - Towards a molecular understanding of membrane-bound proteolytic machines (2012), Biochim. Biophys. Acta, 1823, 49-55.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial inner membrane | - |
Saccharomyces cerevisiae | 5743 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | m-AAA protease ensures maturation of cytochrome c peroxidase 1 (Ccp1). The precursor of Ccp1 is dislocated from the inner mitochondrial membrane to allow cleavage by the rhomboid protease Pcp1. Dislocation depends on the ATPase but not the proteolytic activity of the m-AAA protease | ? | - |
? |  |
| MrpL32 + H2O | Saccharomyces cerevisiae | MrpL32 receives processing by the m-AAA protease after import into the matrix | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | m-AAA protease ensures maturation of cytochrome c peroxidase 1 (Ccp1). The precursor of Ccp1 is dislocated from the inner mitochondrial membrane to allow cleavage by the rhomboid protease Pcp1. Dislocation depends on the ATPase but not the proteolytic activity of the m-AAA protease | Saccharomyces cerevisiae | ? | - |
? | |
| MrpL32 + H2O | MrpL32 receives processing by the m-AAA protease after import into the matrix | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | - |
Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mitochondrial AAA protease | - |
Saccharomyces cerevisiae |
| Yta10 | subunit | Saccharomyces cerevisiae |
| Yta12 | subunit | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | intersubunit coordination of the ATP hydrolysis leads to an ordered ATP hydrolysis within the AAA ring, which ensures efficient substrate dislocation from the membrane and translocation to the proteolytic chamber | Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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