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Literature summary for 3.4.24.B18 extracted from
- Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7 (2009), PLoS ONE, 4, e6975.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| His-tagged version expressed in Escherichia coli BL21(DE3) | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| AAA-domain of paraplegin bound to ADP, vapor diffusion method in sitting drops | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial inner membrane | - |
Homo sapiens | 5743 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UQ90 | PDB enty 2qz4, gene identification code 116242796 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| immobilized metal ion affinity chromatography, gel filtration | Homo sapiens |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homohexamer | paraplegin (SPG7) subunit, crystal structure and homology with FtsH | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| m-AAA protease | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | involved in hereditary spastic paraplegias | Homo sapiens |
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Release 2023.1 (January 2023)
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