Literature summary for 3.4.24.B18 extracted from

Rugarli, E.I.; Langer, T.
Translating m-AAA protease function in mitochondria to hereditary spastic paraplegia (2006), Trends Mol. Med., 12, 262-269.

Search for more literature for 3.4.24.B18

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	active on the matrix side of the inner membrane	Mus musculus	5739	-
mitochondrion	active on the matrix side of the inner membrane	Homo sapiens	5739	-
mitochondrion	active on the matrix side of the inner membrane	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
MrpL32 + H2O	Mus musculus	in vivo substrate, m-AAA does not affect the stability of the protein but cleaves the N-terminal mitochondrial targeting sequence upon protein import into the mitochondrion	?	-	?
MrpL32 + H2O	Homo sapiens	in vivo substrate, m-AAA does not affect the stability of the protein but cleaves the N-terminal mitochondrial targeting sequence upon protein import into the mitochondrion	?	-	?
MrpL32 + H2O	Saccharomyces cerevisiae	in vivo substrate, m-AAA does not affect the stability of the protein but cleaves the N-terminal mitochondrial targeting sequence upon protein import into the mitochondrion	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
MrpL32 + H2O	in vivo substrate, m-AAA does not affect the stability of the protein but cleaves the N-terminal mitochondrial targeting sequence upon protein import into the mitochondrion	Mus musculus	?	-	?
MrpL32 + H2O	in vivo substrate, m-AAA does not affect the stability of the protein but cleaves the N-terminal mitochondrial targeting sequence upon protein import into the mitochondrion	Homo sapiens	?	-	?
MrpL32 + H2O	in vivo substrate, m-AAA does not affect the stability of the protein but cleaves the N-terminal mitochondrial targeting sequence upon protein import into the mitochondrion	Saccharomyces cerevisiae	?	-	?

Subunits

Subunits	Comment	Organism
heterooligomer	-	Mus musculus
heterooligomer	-	Homo sapiens
heterooligomer	-	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
mitochondrial AAA protease	-	Mus musculus
mitochondrial AAA protease	-	Homo sapiens
mitochondrial AAA protease	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)