Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B17 extracted from

  • Okuno, T.; Yamanaka, K.; Ogura, T.
    An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin (2006), Genes Cells, 11, 261-268.
    View publication on PubMed
Search for more literature for 3.4.24.B17

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Protein + H2O Escherichia coli FtsH degrades misassembled membrane proteins and a subset of cytoplasmic regulatory proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apo-flavodoxin + H2O degradation of apo-flavodoxin from Escherichia coli, no degradation of holo-flavodoxin containing non-covalently bound flavin mononucleotide. A mutant flavodoxin carrying a substitution of Tyr94 to Asp (FldYD) with a lower affinity for FMN is efficiently degraded. FtsH is able to initiate degradation of the FldYD moiety even when it is sandwiched by glutathione S-transferase, green fluorescent protein, or both green fluorescent protein and glutathione S-transferase Escherichia coli ?
-
 ?
Protein + H2O FtsH degrades misassembled membrane proteins and a subset of cytoplasmic regulatory proteins Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
FtsH
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Escherichia coli