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Literature summary for 3.4.24.B17 extracted from

  • Krzywda, S.; Brzozowski, A.M.; Verma, C.; Karata, K.; Ogura, T.; Wilkinson, A.J.
    The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution (2002), Structure, 10, 1073-1083.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray structure determination and analysis at about 1.5 A, molecular modeling Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Escherichia coli degrades misassembled membrane protein complexes and plays a vital role in membrane quality control, degrades cytoplasmic regulatory proteins peptides
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins essential for activity are residues Asn301, Asp307, Arg312, and Arg315, mechanism, ligand binding site at residues 144-398 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lambda protein CII + H2O cytoplasmic regulatory protein Escherichia coli ?
-
?
protein + H2O
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Escherichia coli peptides
-
?
protein + H2O degrades misassembled membrane protein complexes and plays a vital role in membrane quality control, degrades cytoplasmic regulatory proteins Escherichia coli peptides
-
?
protein LpxC + H2O cytoplasmic regulatory protein Escherichia coli ?
-
?
protein sigma32 + H2O cytoplasmic regulatory protein Escherichia coli ?
-
?

Subunits

Subunits Comment Organism
hexamer modeling from crystal structure Escherichia coli
More molecular structure model of the AAA domain, intersubunit interactions, overview Escherichia coli

Synonyms

Synonyms Comment Organism
FtsH
-
Escherichia coli
M41.001 Merops-ID Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on, the Walker-type ATPase modul is an alpha/beta-nucleotide binding domain connected to a four-helix bundle Escherichia coli