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Literature summary for 3.4.24.B15 extracted from
- A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells (2012), J. Bone Miner. Res., 27, 453-460.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K496X | mutant mice have increased Fgf23 expression and reduced proteolytic cleavage of intact Fgf23 protein, resulting in markedly elevated intact Fgf23 levels and consequent hypophosphatemia | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein FGF-23 + H2O | Mus musculus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P70669 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein FGF-23 + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PHEX | - |
Mus musculus |
| phosphate-regulating gene with homologies to endopeptidases on the X chromosome | - |
Mus musculus |
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