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Literature summary for 3.4.24.B15 extracted from

  • Rowe, P.S.
    The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled (2012), Cell Biochem. Funct., 30, 355-375.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B15

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloendopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ASARM peptide + H2O Homo sapiens
-
 ?
-
 ?
dentin matrix protein-1 + H2O Homo sapiens
-
 ?
-
 ?
matrix extracellular phosphoglycoprotein + H2O Homo sapiens
-
 ?
-
 ?
osteopontin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78562
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ASARM peptide + H2O
-
 Homo sapiens ?
-
 ?
dentin matrix protein-1 + H2O
-
 Homo sapiens ?
-
 ?
matrix extracellular phosphoglycoprotein + H2O
-
 Homo sapiens ?
-
 ?
osteopontin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PEX formerly Homo sapiens
PHEX
-
 Homo sapiens
phosphate-regulating gene with homologies to endopeptidases on the X chromosome
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction defects in PHEX are responsible for X-linked hypophosphatemic rickets. Loss of enzyme function causes defective mineralization, hypophosphatemia, abnormal vitamin-D metabolism and gross skeletal abnormalities. Loss of enzyme activity leads to increased fibroblast growth factor 23 expression Homo sapiens