Cloned (Comment) | Organism |
---|---|
gene PHEX, localization on the X chromosome, overexpression under control of the human beta-actin promoter in transgenic mice in all tissue except for pancreas, ovary and brain | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of two mouse lines overexpressing human PHEX, the expression of the hunan gene in transgenic mutant Hyp mice does not fully rescue the Hyp mouse phenotype, heterozygous mice show normal bone and mineral ion homeostasis, Hyp mice show reduced body weight, hypophosphatemia, hyperphosphaturia, and rickets, detailed overview | Mus musculus |
additional information | overexpression of human PHEX in enzyme-deficient transgenic mutant Hyp mice does not fully rescue the Hyp mouse phenotype, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | enzyme-deficiency is involved in X-linked hypophosphatemia, Hyp, the enzyme inactivates a phosphaturic factor, which may be fibroblast growth factor 23 | ? | - |
? | |
additional information | Homo sapiens | enzyme-deficiency is involved in X-linked hypophosphatemia, XLH, the enzyme inactivates a phosphaturic factor, which may be fibroblast growth factor 23 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene PHEX | - |
Mus musculus | - |
gene PHEX | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme-deficiency is involved in X-linked hypophosphatemia, Hyp, the enzyme inactivates a phosphaturic factor, which may be fibroblast growth factor 23 | Mus musculus | ? | - |
? | |
additional information | enzyme-deficiency is involved in X-linked hypophosphatemia, XLH, the enzyme inactivates a phosphaturic factor, which may be fibroblast growth factor 23 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHEX | - |
Mus musculus |
PHEX | - |
Homo sapiens |
phosphate-regulating gene with homologies to endiopeptidases on the X chromosome | - |
Homo sapiens |
phosphate-regulating gene with homologies to endopeptidases on the X chromosome | - |
Mus musculus |