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Literature summary for 3.4.24.B15 extracted from

  • Liu, S.; Guo, R.; Simpson, L.G.; Xiao, Z.S.; Burnham, C.E.; Quarles, L.D.
    Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX (2003), J. Biol. Chem., 278, 37419-37426.
    View publication on PubMed
Search for more literature for 3.4.24.B15

Cloned(Commentary)

Cloned (Comment) Organism
functional in vitro expression by a reticulocyte lysate expression system, protein expressed in COS-7 cells is not functional Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Homo sapiens
additional information phosphoramidon is no inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Homo sapiens enzyme mutations are responsible for X-chromosome linked hypophosphataemia by increasing levels of circulating phosphaturic factor peptides
-
 ?
protein FGF-23 + H2O Homo sapiens i.e. fibroblastic growth factor 23, loss of enzyme activity results in either diminished degradation or increased biosynthesis of FGF-23 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information recombinant protein FGF-23, i.e. fibroblastic growth factor 23 seems to be no direct substrate for the enzyme Homo sapiens ?
-
 ?
protein + H2O
-
 Homo sapiens peptides
-
 ?
protein + H2O enzyme mutations are responsible for X-chromosome linked hypophosphataemia by increasing levels of circulating phosphaturic factor Homo sapiens peptides
-
 ?
protein FGF-23 + H2O i.e. fibroblastic growth factor 23 Homo sapiens ?
-
 ?
protein FGF-23 + H2O i.e. fibroblastic growth factor 23, loss of enzyme activity results in either diminished degradation or increased biosynthesis of FGF-23 Homo sapiens ?
-
 ?
Z-Ala-Ala-Leu-4-nitroanilide + H2O chromogenic substrate Homo sapiens Z-Ala-Ala-Leu + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
M13.091 Merops-ID Homo sapiens
PHEX
-
 Homo sapiens