Literature summary for 3.4.24.B14 extracted from

Huang, J.Y.; Hafez, D.M.; James, B.D.; Bennett, D.A.; Marr, R.A.
Altered NEP2 Expression and Activity in Mild Cognitive Impairment and Alzheimers Disease (2012), J. Alzheimers Dis., 28, 433-441.

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Application

Application	Comment	Organism
medicine	altered NEP2 expression in mild cognitive impaired patients may potentially serve as preclinical markers for Alzheimer's disease and reduced NEP2 activity may be associated with the development of Alzheimer's disease	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	NEP2 expression is measured in non-impaired, mild cognitive impaired, and clinical Alzheimer's disease human brain tissue from two Alzheimer's disease -susceptible and two resistant regions. NEP2 and NEP mRNA expression is altered in mild cognitive impaired subjects relative to non-impaired subjects in Alzheimer's disease -susceptible regions. NEP2 enzymatic activity is lowered in association with mild cognitive impaired and Alzheimer's disease and is positively associated with cognitive function, independent of diagnostic category	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NEP2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	NEP2 expression is measured in non-impaired, mild cognitive impaired, and clinical Alzheimer's disease human brain tissue from two Alzheimer's disease -susceptible and two resistant regions. NEP2 and NEP mRNA expression is altered in mild cognitive impaired subjects relative to non-impaired subjects in Alzheimer's disease -susceptible regions. NEP2 enzymatic activity is lowered in association with mild cognitive impaired and Alzheimer's disease and is positively associated with cognitive function, independent of diagnostic category	down

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Release 2023.1 (January 2023)