Literature summary for 3.4.24.B14 extracted from

Hafez, D.; Huang, J.Y.; Huynh, A.M.; Valtierra, S.; Rockenstein, E.; Bruno, A.M.; Lu, B.; DesGroseillers, L.; Masliah, E.; Marr, R.A.
Neprilysin-2 is an important beta-amyloid degrading enzyme (2011), Am. J. Pathol., 178, 306-312.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
neprilysin-2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	mice deficient for the NEP2 gene show significant elevations in total amyloid-beta peptide species in the hippocampus and brainstem/diencephalon (1.5fold). Increases in amyloid-beta peptide accumulation are more dramatic in NEP2 knockout mice crossbred with APP transgenic mice. In NEP/NEP2 double-knockout mice, amyloid-beta peptide levels are marginally increased (1.5 to 2fold), compared with NEP-/-/NEP2+/+ controls. Treatment of these double-knockout mice with phosphoramidon results in elevations of amyloid-beta peptide, suggesting that yet other NEP-like amyloid-beta peptide -degrading endopeptidases are contributing to amyloid-beta peptide catabolism	Mus musculus

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Release 2023.1 (January 2023)