Application | Comment | Organism |
---|---|---|
medicine | ADAMTS-5 is the main aggrecanase in laryngeal squamous cell carcinoma presenting a stage-related increase up to stage III (8fold higher expression compared to normal), and thereafter decreased in stage IV. ADAMTS-5 is highly expressed by carcinoma cells. Within the cancerous and their corresponding macroscopically normal laryngeal tissues, an altered distribution and organization of multiple molecular forms (latent, activated and fragmented forms) of the enzymes is found | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
laryngeal squamous cell carcinoma cell | ADAMTS-5 is the main aggrecanase in laryngeal squamous cell carcinoma | Homo sapiens | - |
larynx | ADAMTS-4, EC 3.4.24.82, is the highest expressed aggrecanase in normal larynx | Homo sapiens | - |