Literature summary for 3.4.24.B12 extracted from

Tortorella, M.D.; Arner, E.C.; Hills, R.; Easton, A.; Korte-Sarfaty, J.; Fok, K.; Wittwer, A.J.; Liu, R.Q.; Malfait, A.M.
Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes (2004), J. Biol. Chem., 279, 17554-17561.

Search for more literature for 3.4.24.B12

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Drosophila SF9 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-2-dimethylamino-N-hydroxy-3,3-dimethyl-4-[(4-phenoxyphenyl)-sulfonyl]-butanamide	SC81956, potent inhibitor of ADAMTS-5	Homo sapiens
alpha2-Macroglobulin	after 10 min 100% and 68% inhibition at concentrations of 2.5 and 7.5 nM, respectively, similar results when using 25 and 75 nM	Homo sapiens
BB-16	(2S,5R,6S)-3-Aza-4-oxo-10-oxa-5-hexyl-2-(methylcarboxamido)-10-paracyclophane-6-N-hydroxycarboxamide	Homo sapiens
additional information	[3S-[3R,2-[2R,2-(R,S)]-hexahydro-2-(2-[2-(hydroxyamino)-1-methyl-2-oxyethyl])-4-methyl-1-oxypentyl]-N-methyl]-3-pyridazinecarboxamide, i.e.XS309 is inactive at less than 0.01 mM in blocking ADAMTS-5	Homo sapiens
tissue inhibitor of matrix metalloproteinases-3	TIMP-3	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	-	Homo sapiens	?	-	?
alpha2-macroglobulin + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ADAMTS-5	-	Homo sapiens
aggrecanase 2	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)