Literature summary for 3.4.24.B11 extracted from

Fernandez-Rodriguez, R.; Rodriguez-Baena, F.J.; Martino-Echarri, E.; Peris-Torres, C.; Del Carmen Plaza-Calonge, M.; Rodriguez-Manzaneque, J.C.
Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis (2016), Oncotarget, 7, 34507-34519 .

Search for more literature for 3.4.24.B11

Application

Application	Comment	Organism
medicine	syngeneic B16F1 melanoma model in wild type and ADAMTS1 knockout mice. Genetic deletion of ADAMTS1 in the host microenvironment results in a drastic decrease of tumor growth and metastasis. Reduced tumors in ADAMTS1 KO mice display a paradoxical increase in vascular density and vascular-related genes with an impaired vasculature, along with a minor infiltration of macrophages. ADAMTS1is involved in vascular sprouting, and melanoma xenografts show a relevant induction of its expression in stroma compartments	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P97857	-	-

Synonyms

Synonyms	Comment	Organism
A Disintegrin And Metalloprotease with ThromboSpondin Repeats 1	-	Mus musculus
ADAMTS1	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)