Literature summary for 3.4.24.B11 extracted from

Fu, Y.; Nagy, J.A.; Brown, L.F.; Shih, S.C.; Johnson, P.Y.; Chan, C.K.; Dvorak, H.F.; Wight, T.N.
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis (2011), J. Histochem. Cytochem., 59, 463-473.

Search for more literature for 3.4.24.B11

Activating Compound

Activating Compound	Comment	Organism	Structure
MMP-15	activates ADAMTS-1	Mus musculus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
110000	-	x * 110000, pro-form, SDS-PAGE	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
versican + H2O	Mus musculus	ADAMTS-1 cleaves versican at the Glu441-Ala442 bond to generate a 70000 Da fragment termed DPEAAE	DPEAAE + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	ADAMTS-1 is localized to developing mother vessel endothelial cells	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
versican + H2O	ADAMTS-1 cleaves versican at the Glu441-Ala442 bond to generate a 70000 Da fragment termed DPEAAE	Mus musculus	DPEAAE + ?	-	?

Subunits

Subunits	Comment	Organism
?	x * 110000, pro-form, SDS-PAGE	Mus musculus

Synonyms

Synonyms	Comment	Organism
ADAMTS-1	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	ADAMTS-1 mRNA expression is strongly, indirectly and progressively upregulated over the period of 30 min to 16 h by vascular endothelial growth factor A	up

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Release 2023.1 (January 2023)