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Literature summary for 3.4.24.B11 extracted from

  • Kaushal, G.P.; Shah, S.V.
    The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family (2000), J. Clin. Invest., 105, 1335-1337.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B11

Protein Variants

Protein Variants Comment Organism
additional information knock-out mutant shows a phenotype with reduced growth and body weight, as well as pathological changes in the kidney structure, obstructive fibrosis, disrupted capillary networks in the adrenal gland, and hypoplastic or atrophic papillae Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion Mus musculus
-
-
membrane associated Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on, metalloproteinase, consensus sequence HEXXH Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme plays a role in cell-cell and cell-matrix interactions, in cell adhesion and growth factor signaling ?
-
 ?
proteins + H2O Mus musculus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 enzyme belongs to the subfamily of adamalysins which is part of the superfamily of zinc-dependent proteases
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme is synthesized as an inactive proform, proteolytical processing of a conserved cysteine residue in its prodomain Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays a role in cell-cell and cell-matrix interactions, in cell adhesion and growth factor signaling Mus musculus ?
-
 ?
proteins + H2O
-
 Mus musculus peptides
-
 ?

Subunits

Subunits Comment Organism
More enzyme is a multidomain protease possessing a prodomain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail Mus musculus

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Mus musculus
ADAMTS-1
-
 Mus musculus
M12.222 Merops-ID Mus musculus