Cloned (Comment) | Organism |
---|---|
expression as Myc-His-tagged wild-type and truncated mutant in 293T cell line | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation | ? | - |
? | |
proteins + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | secreted pro-METH-1 is processed in 2 consecutive steps to release a p87 and a p65 active form, cleavage by furin results in only the p87 fragment, the p87 form lacks the N-terminal prodomain, and p65 results from an additional processing event in the C-terminus requiring p87 which can be catalyzed by matrix metalloproteases 2,8, and 15 | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant Myc-His-tagged enzyme from cell line 293T | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation | Homo sapiens | ? | - |
? | |
proteins + H2O | - |
Homo sapiens | peptides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
M12.222 | Merops-ID | Homo sapiens |
METH-1 | - |
Homo sapiens |