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Literature summary for 3.4.24.B11 extracted from

  • Iruela-Arispe, M.L.; Carpizo, D.; Luque, A.
    ADAMTS1: a matrix metalloprotease with angioinhibitory properties (2003), Ann. N. Y. Acad. Sci., 995, 183-190.
    View publication on PubMed
Search for more literature for 3.4.24.B11

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-Myc-tagged wild-type enzyme and tagged mutant E385A, as well as truncated construct comprising the amino acid residues 549-951, in the carcinoma cell line T47D Homo sapiens

Protein Variants

Protein Variants Comment Organism
E385A point mutation in the zinc binding domain, catalytically inactive mutant Homo sapiens
additional information induction of tumor growth in nude mice by injection of carcinoma cells, cell line T47D expressing the recombinant His-Myc-tagged wild-type or mutant E385A enzyme, number and distribution of vessels in the tumors are reduced compared to control tumors, high degree of edema and necrosis, the truncated construct comprising the amino acid residues 549-951 had no effect on tumor growth, but the isolated first TSP1 repeat does Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium ?
-
 ?
proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins C-terminal catalytic domain Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
T47-D cell low expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor Homo sapiens ?
-
 ?
additional information interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium Homo sapiens ?
-
 ?
proteins + H2O
-
 Homo sapiens peptides
-
 ?
proteins + H2O rather restricted substrate specificity Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS1
-
 Homo sapiens
M12.222 Merops-ID Homo sapiens
METH1
-
 Homo sapiens