Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43184 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloprotease with thrombospondin motifs 12 | - |
Homo sapiens |
ADAMTS-12 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAMTS-12 is involved in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation. The enzyme is also involved in the processes of chondrocyte differentiation and cartilage development | Homo sapiens |