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Literature summary for 3.4.24.B10 extracted from

  • Wei, J.; Richbourgh, B.; Jia, T.; Liu, C.
    ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation (2014), Mediators Inflamm., 2014, 649718.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens O43184
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-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease with thrombospondin motifs 12
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Homo sapiens
ADAMTS-12
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Homo sapiens

General Information

General Information Comment Organism
physiological function ADAMTS-12 is involved in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation. The enzyme is also involved in the processes of chondrocyte differentiation and cartilage development Homo sapiens