Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Rituximab | a monoclonal anti-CD 20 antibody, Rituximab leads to a prompt reduction in IgG antibody levels, followed by an increase in ADAMTS 13 activity increases. However, in patients receiving Rituximab electively, normalisation of ADAMTS 13 enzyme activity may be delayed for up to 3 months | Homo sapiens |
Application | Comment | Organism |
---|---|---|
diagnostics | role of ADAMTS 13 assays in diagnosis and prognosis of thrombotic thrombocytopenic purpura, TTP, overview | Homo sapiens |
drug development | inhibitory anti-ADAMTS 13 antibodies, measurement and clinical application, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibitory anti-ADAMTS 13 antibodies, measurement and clinical application, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | metalloprotease ADAMTS-13 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS 13 | - |
Homo sapiens |
metalloprotease ADAMTS-13 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAMTS-13 deficiency is the cause for thrombotic thrombocytopenic purpura is an acute life threatening disorder, characterised by thrombocytopenia, microangiopathic haemolytic anaemia and multi organ microvascular thrombi that results in variable clinical symptoms | Homo sapiens |