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Literature summary for 3.4.24.87 extracted from

  • Kokame, K.; Matsumoto, M.; Fujimura, Y.; Miyata, T.
    VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13 (2003), Blood, 103, 607-612.
    View publication on PubMed
Search for more literature for 3.4.24.87

Activating Compound

Activating Compound Comment Organism Structure
Urea required Homo sapiens

Application

Application Comment Organism
medicine VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13. VWF73 could be a powerful tool to establish clinical enzymatic assays. It may contribute to improve the prognosis and prevention of thrombotic thrombocytopenic purpurea Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of a series of partial deletions in the A2 domain flanked with N- and C-terminal tags in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition by autoantibodies from patients with acquired thrombotic thrombocytopenic purpura Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens
-
 peptides
-
 ?
von Willebrand factor + H2O Homo sapiens either congenital or acquired defects of the enzyme lead to thrombotic thromcytopenic purpura, cleavage of the peptide bond bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 2 peptides of 140 kDa and 176 kDa
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant tagged deletion mutants Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain enzyme is a hemostatic factor Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proteins + H2O
-
 Homo sapiens peptides
-
 ?
von Willebrand factor + H2O specific cleavage of the peptide bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?
von Willebrand factor + H2O either congenital or acquired defects of the enzyme lead to thrombotic thromcytopenic purpura, cleavage of the peptide bond bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?
von Willebrand factor + H2O VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13 Homo sapiens ?
-
 ?
VWF73 region of von Willebrand factor + H2O with this minimal substrate urea is not required for cleavage, minimal substrate for ADAMTS-13 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-13
-
 Homo sapiens
M12.241 Merops-ID Homo sapiens
von Willebrand factor-cleaving protease
-
 Homo sapiens