Literature summary for 3.4.24.86 extracted from

DeBerge, M.; Ely, K.; Cheng, G.; Enelow, R.
ADAM17-mediated processing of TNF-alpha expressed by antiviral effector CD8+ T cells is required for severe T-cell-mediated lung injury (2013), PLoS ONE, 8, e79340.

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Application

Application	Comment	Organism
medicine	inhibition of ADAM17-mediated processing of TNF-alpha by CD8+ T cells significantly attenuates the diffuse alveolar damage that occurs after T-cell transfer, resulting in enhanced survival. TNF-alpha processing is required for lung epithelial cell expression of CXCL2 and the subsequent inflammatory infiltration. CXCL2 expression is important in acute lung injury	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9Z0F8	-	-

General Information

General Information	Comment	Organism
physiological function	inhibition of ADAM17-mediated processing of TNF-alpha by CD8+ T cells significantly attenuates the diffuse alveolar damage that occurs after T-cell transfer, resulting in enhanced survival. TNF-alpha processing is required for lung epithelial cell expression of CXCL2 and the subsequent inflammatory infiltration. CXCL2 expression is important in acute lung injury	Mus musculus

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Release 2023.1 (January 2023)