Crystallization (Comment) | Organism |
---|---|
docking of nine-residue peptide PLAQA-VRSS from proTNF-alpha. The peptide adopts an anti-parallel beta-sheet conformation against a nearby beta-sheet of the protein. In the complexmodel, the side-chains of residues P2 and P2' are largely exposed,and do not form highly favorable interactions | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78536 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | mutations at the P2 site and the P2' site of the substrate peptide largely affect the peptide cleavage efficiency in the enzymaticassay. The P2/P2'sites may affect the efficiency of the conformation search for the correct peptide orientation, which in turn affects the substrate cleavage efficiency. Peptide PRYEA?YKMG is not a substrate | Homo sapiens | ? | - |
? | |
PLAAAVFSS + H2O | mutant peptide derived from TNF-alpha, very poor substrate | Homo sapiens | PLAAA + VFSS | - |
? | |
PLAMAVMSS + H2O | mutant peptide derived from TNF-alpha, very poor substrate | Homo sapiens | PLAMA + VMSS | - |
? | |
PLAQAVRSS + H2O | peptide derived from TNF-alpha | Homo sapiens | PLAQA + VRSS | - |
? |