Literature summary for 3.4.24.86 extracted from

Marczynska, J.; Ozga, A.; Wlodarczyk, A.; Majchrzak-Gorecka, M.; Kulig, P.; Banas, M.; Michalczyk-Wetula, D.; Majewski, P.; Hutloff, A.; Schwarz, J.; Chalaris, A.; Scheller, J.; Rose-John, S.; Cichy, J.
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses (2014), J. Immunol., 193, 2753-2763.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9Z0F8	-	-

General Information

General Information	Comment	Organism
physiological function	in ADAM17 hypomorphic mice, in which ADAM17 expression is reduced by 90-95% compared with wild-type littermates, ADAM17 deficiency results in spleen and lymph node enlargement, as well as increased levels of Ag-specific class-switched Ig production following immunization with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid. The costimulatory ligand ICOS (ICOSL) is selectively downregulated on the surface of B cells in an ADAM17-specific manner	Mus musculus

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Release 2023.1 (January 2023)