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Literature summary for 3.4.24.86 extracted from

  • Pradines, E.; Loubet, D.; Mouillet-Richard, S.; Manivet, P.; Launay, J.M.; Kellermann, O.; Schneider, B.
    Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells (2009), J. Neurochem., 110, 912-923.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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General Information

General Information Comment Organism
physiological function in 1C11-derived neuronal cells, antibody-mediated prion protein ligation triggers TNF-alpha release, through recruitement of the metalloproteinase TNF-alpha converting enzyme TACE. TNF-alpha shed in response to prion protein acts as a second message signal, eliciting serotonin or norepinephrine degradation in 1C115-HT or 1C11NE cells, respectively Mus musculus