Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | in 1C11-derived neuronal cells, antibody-mediated prion protein ligation triggers TNF-alpha release, through recruitement of the metalloproteinase TNF-alpha converting enzyme TACE. TNF-alpha shed in response to prion protein acts as a second message signal, eliciting serotonin or norepinephrine degradation in 1C115-HT or 1C11NE cells, respectively | Mus musculus |