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Literature summary for 3.4.24.85 extracted from

  • Lee, K.; Tirasophon, W.; Shen, X.; Michalak, M.; Prywes, R.; Okada, T.; Yoshida, H.; Mori, K.; Kaufman, R.
    IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response (2002), Genes Dev., 16, 452-466.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATF6 + H2O Cricetulus griseus
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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Source Tissue

Source Tissue Comment Organism Textmining
ovary cell line CHO-K1 wild type and M19 S2P deficient cell lines Cricetulus griseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATF6 + H2O
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 Cricetulus griseus ?
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 ?
ATF6 + H2O cleavage in site-2 is required for induction of IRE1-alpha and ER-stress activated target genes Cricetulus griseus ?
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