Literature summary for 3.4.24.83 extracted from

Kassab, E.; Darwish, M.; Timsah, Z.; Liu, S.; Leppla, S.; Frankel, A.; Abi-Habib, R.
Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity (2013), Transl. Oncol., 6, 25-32.

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Application

Application	Comment	Organism
medicine	seven of eleven acute myeloid leukemia cell lines show cytotoxic responses to anthrax lethal toxin LeTx. Cytotoxicity is mimicked by the specific mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor U0126, indicating involvement of the ERK1/2 branch of the MAPK pathway. The four LeTx-resistant cell lines are sensitive to the phosphatidylinositol 3-kinase inhibitor LY294002. with a lack of additive/synergistic effects when both pathways are inhibited. Phospho-ERK1/2 is only present in LeTx-sensitive cells. LeTx-induced cell death is caspase-independent and nonapoptotic	Bacillus anthracis

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	P15917	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
LeTx	-	Bacillus anthracis

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Release 2023.1 (January 2023)