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Literature summary for 3.4.24.83 extracted from

  • Levinsohn, J.; Newman, Z.; Hellmich, K.; Fattah, R.; Getz, M.; Liu, S.; Sastalla, I.; Leppla, S.; Moayeri, M.
    Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome (2012), PLoS Pathog., 8, e1002638.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Bacillus anthracis P15917
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NOD-like receptor protein-1 + H2O lethal factor cleaves rat NOD-like receptor protein Nlrp1. Cleavage is required for toxin-induced inflammasome activation, interleukin IL-1beta release, and macrophage pyroptosis Bacillus anthracis ?
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