Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
MAP kinase kinase 3b + H2O | Bacillus anthracis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MAP kinase kinase 3b + H2O | - |
Bacillus anthracis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
anthrax lethal factor | - |
Bacillus anthracis |
LeTx | lethal toxin is composed of lethal factor and the protective antigen | Bacillus anthracis |
General Information | Comment | Organism |
---|---|---|
physiological function | treatment of rat pulmonary microvascular endothelial cells with anthrax lethal toxin (LeTx) increases endothelial barrier permeability and gap formation between endothelial cells through disrupting p38 signaling. LeTxr educes phosphorylation of p38, MAP kinase 2, and HSP27 | Bacillus anthracis |