Literature summary for 3.4.24.83 extracted from

Kong, Y.; Guo, Q.; Yu, C.; Dong, D.; Zhao, J.; Cai, C.; Hou, L.; Song, X.; Fu, L.; Xu, J.; Chen, W.
Fusion protein of DELTA 27LFn and EFn has the potential as a novel anthrax toxin inhibitor (2009), FEBS Lett., 583, 1257-1260.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	fusion protein of N-terminal 27 amino acids deletion of protective antigen-binding domain of anthrax lethal factor Delta27LFn and protective antigen-binding domain of edema factor is a 62-fold more potent toxin inhibitor than protective antigen-binding domain of anthrax lethal factor or protective antigen-binding domain of edema factor in a cell model of intoxication, and this increased activity corresponds to a 39-fold higher protective antigen-binding affinity by Biacore analysis. The fusion protein can protect the highly susceptible Fischer 344 rats from anthrax lethal toxin challenge	Bacillus anthracis

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

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Release 2023.1 (January 2023)