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Literature summary for 3.4.24.83 extracted from

  • Alfano, R.W.; Leppla, S.H.; Liu, S.; Bugge, T.H.; Meininger, C.J.; Lairmore, T.C.; Mulne, A.F.; Davis, S.H.; Duesbery, N.S.; Frankel, A.E.
    Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis (2009), Mol. Cancer Res., 7, 452-461.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine engineered lethal anthrax toxin prevents tumor growth by inhibiting angiogenesis (10 nmol/l engineered protective antigen + 5.5 nmol/l lethal factor) Bacillus anthracis

Protein Variants

Protein Variants Comment Organism
additional information non-specific furin cleavage sequence (164RKKR167) of the protective antigen of anthrax toxin is substituted by the cleavage sequence for gelatinase class of matrix metalloproteinase (164GPLGMLSQ171) to prevent non-specific action and enhance target specific action in endothelial cells Bacillus anthracis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus anthracis anthrax lethal factor cleaves and inactivates extracellular signal-regulated kinase kinases of the mitogen-activated protein kinase pathway in human dermal microvascular endothelial cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information anthrax lethal factor cleaves and inactivates extracellular signal-regulated kinase kinases of the mitogen-activated protein kinase pathway in human dermal microvascular endothelial cells Bacillus anthracis ?
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 ?

Synonyms

Synonyms Comment Organism
anthrax lethal toxin
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 Bacillus anthracis