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Literature summary for 3.4.24.82 extracted from

  • Tauchi, R.; Imagama, S.; Natori, T.; Ohgomori, T.; Muramoto, A.; Shinjo, R.; Matsuyama, Y.; Ishiguro, N.; Kadomatsu, K.
    The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury (2012), J. Neuroinflammation, 9, 53.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 x * 68000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9ESP7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
brevican + H2O
-
 Rattus norvegicus ?
-
 ?
neurocan + H2O
-
 Rattus norvegicus ?
-
 ?
phosphacan + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, SDS-PAGE Rattus norvegicus

General Information

General Information Comment Organism
physiological function ADAMTS-4 digests proteoglycans, and reverses their inhibition of neurite outgrowth. Local administration of ADAMTS-4 significantly promotes motor function recovery after spinal cord injury. The ADAMTS-4-treated spinal cord exhibits enhanced axonal regeneration/sprouting after spinal cord injury Rattus norvegicus