Activating Compound | Comment | Organism | Structure |
---|---|---|---|
IL-1beta | 10 ng/ml, 20 min, upregulation of ADAMTS-4 only in presence of adaptor proteins MyD88, IRAK1 and TRAF6 | Homo sapiens | |
TNF-alpha | 10 ng/ml | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | down-regulation of IL-1beta-induced ADAMTS-4 activation by Ras knockdown or inhibition of reactive oxygen species by antioxidants along with ablation of MyD88, IRAK1, or TRAF6; inducing effect of IL-1beta partially blocked by knockdown of adaptor proteins MyD88, IRAK1 or TRAF6 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
articular cartilage | - |
Homo sapiens | - |
chondrocyte | - |
Homo sapiens | - |
knee | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS-4 | - |
Homo sapiens |
aggrecanase-1 | - |
Homo sapiens |