Activating Compound | Comment | Organism | Structure |
---|---|---|---|
C-terminal thrombospondin type I motif of ADAMTS-5 | addition of the C-terminal thrombospondin type I motif of ADAMTS-5 to the C terminus of ADAMTS-4 increases the activity of ADAMTS-4 against aggrecan and fibromodulin severalfold | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HEK293-EBNA cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
heparin | 0.1 mg/ml, selective inhibition of full-length ADAMTS-4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
anti-FLAG M2-agarose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | - |
Homo sapiens | fragments of aggrecan | - |
? | |
fibromodulin + H2O | cleaves at the Tyr44-Ala45 bond | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase with thrombospondin motifs-4 | - |
Homo sapiens |
ADAMTS-4 | - |
Homo sapiens |
aggrecanase-1 | - |
Homo sapiens |