Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1 | - |
Mus musculus | |
interleukin-1 | - |
Homo sapiens | |
interleukin-1 | - |
Sus scrofa | |
interleukin-1 | - |
Bos taurus | |
additional information | not stimulated by phorbol ester | Mus musculus | |
additional information | not stimulated by phorbol ester | Homo sapiens | |
additional information | not stimulated by phorbol ester | Sus scrofa | |
additional information | not stimulated by phorbol ester | Bos taurus | |
NFkappaB | - |
Mus musculus | |
NFkappaB | - |
Homo sapiens | |
NFkappaB | - |
Sus scrofa | |
NFkappaB | - |
Bos taurus | |
oncostatin M | - |
Mus musculus | |
oncostatin M | - |
Homo sapiens | |
oncostatin M | - |
Sus scrofa | |
oncostatin M | - |
Bos taurus | |
transforming growth factor beta | - |
Mus musculus | |
transforming growth factor beta | - |
Homo sapiens | |
transforming growth factor beta | - |
Sus scrofa | |
transforming growth factor beta | - |
Bos taurus | |
Tumor necrosis factor alpha | - |
Mus musculus | |
Tumor necrosis factor alpha | - |
Homo sapiens | |
Tumor necrosis factor alpha | - |
Sus scrofa | |
Tumor necrosis factor alpha | - |
Bos taurus |
Application | Comment | Organism |
---|---|---|
medicine | therapeutic target in osteoarthritis | Mus musculus |
medicine | therapeutic target in osteoarthritis | Homo sapiens |
medicine | therapeutic target in osteoarthritis | Sus scrofa |
medicine | therapeutic target in osteoarthritis | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Mus musculus | - |
cartilage | - |
Homo sapiens | - |
cartilage | - |
Sus scrofa | - |
cartilage | - |
Bos taurus | - |
chondrocyte | - |
Mus musculus | - |
chondrocyte | - |
Homo sapiens | - |
chondrocyte | - |
Sus scrofa | - |
chondrocyte | - |
Bos taurus | - |
macrophage | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
macrophage | - |
Sus scrofa | - |
macrophage | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | cleaves the Glu373-Ala374 bond | Mus musculus | fragments of aggrecan | - |
ir | |
aggrecan + H2O | cleaves the Glu373-Ala374 bond | Homo sapiens | fragments of aggrecan | - |
ir | |
aggrecan + H2O | cleaves the Glu373-Ala374 bond | Sus scrofa | fragments of aggrecan | - |
ir | |
aggrecan + H2O | cleaves the Glu373-Ala374 bond | Bos taurus | fragments of aggrecan | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS4 | - |
Mus musculus |
ADAMTS4 | - |
Homo sapiens |
ADAMTS4 | - |
Sus scrofa |
ADAMTS4 | - |
Bos taurus |
aggrecanase-1 | - |
Mus musculus |
aggrecanase-1 | - |
Homo sapiens |
aggrecanase-1 | - |
Sus scrofa |
aggrecanase-1 | - |
Bos taurus |