Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1beta | 10 ng/ml | Homo sapiens | |
oncostatin M | dose-depedent stimulation of expression, 1-100 ng/ml | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG490 | 0.01 mM | Homo sapiens | |
Janus kinase 2 inhibitor | 10 g/ml | Homo sapiens | |
Janus kinase 3 inhibitor | 30 g/ml | Homo sapiens | |
LY294002 | 0.01 mM, reduces ADAMTS-4 expression | Homo sapiens | |
NL-71-101 | 0.02 mM, reduces ADAMTS-4 expression | Homo sapiens | |
parthenolide | 0.005 mM, reduces ADAMTS-4 expression | Homo sapiens | |
phosphatidylinositol 3-kinase | reduces ADAMTS-4 expression | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | articular chondrocyte | Homo sapiens | - |
SW-1353 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | - |
Homo sapiens | fragments of aggrecan | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase with thrombospondin motifs-4 | - |
Homo sapiens |
ADAMTS-4 | - |
Homo sapiens |
aggrecanase-1 | - |
Homo sapiens |