Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-(biphenyl-4-ylsulfonyl)-3-(1H-indol-2-yl)propanoic acid | IC50: 0.0028 mM | Rattus norvegicus | |
(2R)-2-(biphenyl-4-ylsulfonyl)-3-phenylpropanoic acid | IC50: 0.0043 mM | Rattus norvegicus | |
(2R)-2-(biphenyl-4-ylsulfonyl)pentanedioic acid | IC50: 0.0011 mM | Rattus norvegicus | |
(2R)-2-(biphenyl-4-ylsulfonyl)propanoic acid | IC50: 0.0055 mM | Rattus norvegicus | |
3-[(biphenyl-4-ylsulfonyl)amino]-4-methylpentanoic acid | IC50: 0.1 mM | Rattus norvegicus | |
N-(biphenyl-3-ylsulfonyl)-D-valine | IC50: 0.1 mM | Rattus norvegicus | |
N-(biphenyl-4-ylsulfonyl)-D-valine | IC50: 0.003 mM | Rattus norvegicus | |
N-(biphenyl-4-ylsulfonyl)-L-valine | IC50: 0.1 mM | Rattus norvegicus | |
N-(biphenyl-4-ylsulfonyl)-N-(pyridin-3-ylmethyl)-D-valine | IC50: 0.012 mM | Rattus norvegicus | |
N-(biphenyl-4-ylsulfonyl)-N-methyl-D-valine | IC50: 0.0016 mM | Rattus norvegicus | |
N-([4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl]sulfonyl)-D-valine | IC50: 0.0075 mM | Rattus norvegicus | |
N-([4'-[(1-benzofuran-2-ylcarbonyl)oxy]biphenyl-4-yl]sulfonyl)-D-valine | IC50: 0.00035 mM | Rattus norvegicus | |
N-([4'-[(furan-2-yloxy)carbonyl]biphenyl-4-yl]sulfonyl)-D-valine | IC50: 0.0116 mM | Rattus norvegicus | |
N-([4'-[(Z)-2-(1-benzofuran-2-yl)ethenyl]biphenyl-4-yl]sulfonyl)-D-valine | IC50: 0.0004 mM | Rattus norvegicus | |
N-([4'-[2-(1-benzofuran-2-yl)-2-oxoethyl]biphenyl-4-yl]sulfonyl)-D-valine | IC50: 0.0038 mM | Rattus norvegicus | |
N-[(2'-aminobiphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.05 mM | Rattus norvegicus | |
N-[(2'-hydroxybiphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.02 mM | Rattus norvegicus | |
N-[(2-aminobiphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.03 mM | Rattus norvegicus | |
N-[(3'-hydroxybiphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.009 mM | Rattus norvegicus | |
N-[(4'-hydroxybiphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.0046 mM | Rattus norvegicus | |
N-[(4'-[[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy]biphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.000086 mM | Rattus norvegicus | |
N-[(4'-[[(3-methyl-1-benzofuran-2-yl)oxy]methyl]biphenyl-4-yl)sulfonyl]-D-valine | IC50: 0.0007 mM | Rattus norvegicus | |
N-[[4'-(1-benzofuran-2-ylmethoxy)biphenyl-4-yl]sulfonyl]-D-valine | IC50: 0.0014 mM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | - |
Rattus norvegicus | fragments of aggrecan | - |
? |
Synonyms | Comment | Organism |
---|---|---|
agg-1 | - |
Rattus norvegicus |
aggrecanase-1 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000086 | - |
IC50: 0.000086 mM | Rattus norvegicus | N-[(4'-[[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy]biphenyl-4-yl)sulfonyl]-D-valine | |
0.00035 | - |
IC50: 0.00035 mM | Rattus norvegicus | N-([4'-[(1-benzofuran-2-ylcarbonyl)oxy]biphenyl-4-yl]sulfonyl)-D-valine | |
0.0004 | - |
IC50: 0.0004 mM | Rattus norvegicus | N-([4'-[(Z)-2-(1-benzofuran-2-yl)ethenyl]biphenyl-4-yl]sulfonyl)-D-valine | |
0.0007 | - |
IC50: 0.0007 mM | Rattus norvegicus | N-[(4'-[[(3-methyl-1-benzofuran-2-yl)oxy]methyl]biphenyl-4-yl)sulfonyl]-D-valine | |
0.0011 | - |
IC50: 0.0011 mM | Rattus norvegicus | (2R)-2-(biphenyl-4-ylsulfonyl)pentanedioic acid | |
0.0014 | - |
IC50: 0.0014 mM | Rattus norvegicus | N-[[4'-(1-benzofuran-2-ylmethoxy)biphenyl-4-yl]sulfonyl]-D-valine | |
0.0016 | - |
IC50: 0.0016 mM | Rattus norvegicus | N-(biphenyl-4-ylsulfonyl)-N-methyl-D-valine | |
0.0028 | - |
IC50: 0.0028 mM | Rattus norvegicus | (2R)-2-(biphenyl-4-ylsulfonyl)-3-(1H-indol-2-yl)propanoic acid | |
0.003 | - |
IC50: 0.003 mM | Rattus norvegicus | N-(biphenyl-4-ylsulfonyl)-D-valine | |
0.0038 | - |
IC50: 0.0038 mM | Rattus norvegicus | N-([4'-[2-(1-benzofuran-2-yl)-2-oxoethyl]biphenyl-4-yl]sulfonyl)-D-valine | |
0.0043 | - |
IC50: 0.0043 mM | Rattus norvegicus | (2R)-2-(biphenyl-4-ylsulfonyl)-3-phenylpropanoic acid | |
0.0046 | - |
IC50: 0.0046 mM | Rattus norvegicus | N-[(4'-hydroxybiphenyl-4-yl)sulfonyl]-D-valine | |
0.0055 | - |
IC50: 0.0055 mM | Rattus norvegicus | (2R)-2-(biphenyl-4-ylsulfonyl)propanoic acid | |
0.0075 | - |
IC50: 0.0075 mM | Rattus norvegicus | N-([4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl]sulfonyl)-D-valine | |
0.009 | - |
IC50: 0.009 mM | Rattus norvegicus | N-[(3'-hydroxybiphenyl-4-yl)sulfonyl]-D-valine | |
0.0116 | - |
IC50: 0.0116 mM | Rattus norvegicus | N-([4'-[(furan-2-yloxy)carbonyl]biphenyl-4-yl]sulfonyl)-D-valine | |
0.012 | - |
IC50: 0.012 mM | Rattus norvegicus | N-(biphenyl-4-ylsulfonyl)-N-(pyridin-3-ylmethyl)-D-valine | |
0.02 | - |
IC50: 0.02 mM | Rattus norvegicus | N-[(2'-hydroxybiphenyl-4-yl)sulfonyl]-D-valine | |
0.03 | - |
IC50: 0.03 mM | Rattus norvegicus | N-[(2-aminobiphenyl-4-yl)sulfonyl]-D-valine | |
0.05 | - |
IC50: 0.05 mM | Rattus norvegicus | N-[(2'-aminobiphenyl-4-yl)sulfonyl]-D-valine | |
0.1 | - |
IC50: 0.1 mM | Rattus norvegicus | N-(biphenyl-3-ylsulfonyl)-D-valine | |
0.1 | - |
IC50: 0.1 mM | Rattus norvegicus | N-(biphenyl-4-ylsulfonyl)-L-valine | |
0.1 | - |
IC50: 0.1 mM | Rattus norvegicus | 3-[(biphenyl-4-ylsulfonyl)amino]-4-methylpentanoic acid |