Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14672 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | ADAM10 specifically localizes in the CD31+ endothelial cells in normal human cardiac tissues and in cultured primary arterial endothelial cells | Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | endopeptidase ADAM10 selectively regulates Notch receptors and ligands in en dothelial cells and promotes Dll4 expression. ADAM10 mediates a canonical Notch dependent release of interleukin IL-6, dependent of gamma-secretase activity. The production of IL-6 through ADAM10/Notch signaling in endothelial cells requires the involvement of the phosphoinositol 3-kinase pathway | Homo sapiens |