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Literature summary for 3.4.24.81 extracted from

  • Blume, K.E.; Soeroes, S.; Keppeler, H.; Stevanovic, S.; Kretschmer, D.; Rautenberg, M.; Wesselborg, S.; Lauber, K.
    Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic find-me signal (2012), J. Immunol., 188, 135-145.
    View publication on PubMed
Search for more literature for 3.4.24.81

Inhibitors

Inhibitors Comment Organism Structure
GI254023X ADAM10 specific inhibitor Homo sapiens
GW 280264X ADAM10/17 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
annexin A1 + H2O Homo sapiens ADAM10 cleaves within the N-terminal domain after Phe7, cleavage occurs on the outer cell surface during secondary but not primary necrosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
HUT-78 cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
MOLT-4 cell
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
annexin A1 + H2O ADAM10 cleaves within the N-terminal domain after Phe7, cleavage occurs on the outer cell surface during secondary but not primary necrosis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM10
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function annexin A1 proteolytic processing by ADAM10 into a chemotactic peptide represents a final events during apoptosis, which after the transition to secondary necrosis contributes to the recruitment of monocytes and the prevention of inflammation Homo sapiens