Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
germinal center | - |
Mus musculus | - |
Peyer's patch | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid precursor protein + H2O | - |
Mus musculus | sAPP-alpha fragment of beta-amyloid precursor protein + C-terminal fragment of beta-amyloid precursor protein | - |
? | |
Notch1 + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase 10 | - |
Mus musculus |
ADAM10 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | ADAM10 levels are significantly enhanced on germinal center B cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | B-cell specific ADAM10 deficient mice have severely diminished primary and secondary responses after T-dependent immunization, display impaired germinal center formation, have fewer follicular T helper cells, decreased follicular dendritic cell networks, and altered chemokine expression in draining lymph nodes | Mus musculus |
physiological function | ADAM10 is essential for the maintenance of lymphoid structure after antigen challenge | Mus musculus |