Application | Comment | Organism |
---|---|---|
medicine | upregulation of ADAM10 is a therapeutic target in Alzheimers disease | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S441A | the mutant displays higher susceptibility to proteolysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vesicle | exosomal | Homo sapiens | 31982 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | ADAm10 possesses four potential N-glycosylation sites | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase 10 | - |
Homo sapiens |
ADAM10 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ADAM10 mRNA is lowered in moderate to severe Alzheimers disease | down |
Homo sapiens | amount and activity of ADAM10 is increased by application of low doses of statins | up |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAM10 is the major alpha-secretase in vivo | Homo sapiens |