Literature summary for 3.4.24.81 extracted from

Mezyk-Kopec R.; Bzowska, M.; Stalinska, K.; Chelmicki, T.; Podkalicki, M.; Jucha, J.; Kowalczyk, K.; Mak, P.; Bereta, J.
Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts (2009), Cytokine, 46, 309-315.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	ADAM17-/-, Ras-Myc-immortalized murine fibroblasts. ADAM10 is a major TNF sheddase in ADAM17-deficient fibroblasts	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	ADAM10 is a major TNF sheddase in ADAM17-deficient fibroblasts. TNF is a major pro-inflammatory cytokine with broad immune effects	Mus musculus

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Release 2023.1 (January 2023)