Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | 0.001 mM, stimulates the cleavage of the extracellular domain of Klotho | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | 10 mM | Homo sapiens | |
EGTA | 10 mM | Homo sapiens | |
additional information | TMP-1 and TIMP-2 do not inhibit shedding of Klotho by ADAM10 | Homo sapiens | |
TAPI-1 | 0.05 mM | Homo sapiens | |
TIMP-3 | - |
Homo sapiens | |
Wortmannin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
extracellular domain of Klotho + H2O | - |
Homo sapiens | 130000 Da Klotho fragment + 68000 Da Klotho fragment | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase 10 | - |
Homo sapiens |
ADAM10 | - |
Homo sapiens |