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Literature summary for 3.4.24.81 extracted from

  • Maretzky, T.; Reiss, K.; Ludwig, A.; Buchholz, J.; Scholz, F.; Proksch, E.; de Strooper, B.; Hartmann, D.; Saftig, P.
    ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation (2005), Proc. Natl. Acad. Sci. USA, 102, 9182-9187.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Activating Compound

Activating Compound Comment Organism Structure
ionomycin 0.005 mM, strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment Homo sapiens
ionomycin strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment Mus musculus
phorbol-12 myristate 13-acetate clearly enhanced epithelial cadherin shedding Mus musculus
phorbol-12 myristate 13-acetate clearly enhanced epithelial cadherin shedding Homo sapiens
staurosporine strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment Mus musculus
staurosporine strongly increases the generation of epithelial cadherin 38 kDa-C-terminal fragment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GI254023X 0.005 mM, with or without 0.001 mM gamma-secretase inhibitor L-685,458 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-
keratinocyte
-
 Mus musculus
-
keratinocyte cell line HaCaT Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epithelial cadherin + H2O
-
 Mus musculus 38-kDa C-terminal fragment + ?
-
 ?
epithelial cadherin + H2O
-
 Homo sapiens 38-kDa C-terminal fragment + ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM10 a disintegrin and metalloprotease Mus musculus
ADAM10 a disintegrin and metalloprotease Homo sapiens
kuzbanian
-
 Mus musculus
kuzbanian
-
 Homo sapiens