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Literature summary for 3.4.24.81 extracted from
- Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines (2004), J. Neurochem., 90, 1489-1499.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| donepezil | because donepezil-treated cells show an increase in the metabolic active form of ADAM 10, this suggests that donepezil may cause a direct increase in the level of ADAM 10 in cellular membranes | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
SDS-PAGE, metabolically active form of ADAM 10 | Homo sapiens |
| 85000 | - |
SDS-PAGE, nonenzymatically active proenzyme of ADAM 10 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuroblastoma cell | strain SH-SY5Y | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | - |
Homo sapiens | sAPP-alpha fragment + C-terminal fragment | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM10 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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